Shahrekord University of Medical Sciences Epidemiology and Health System Journal 2980-7891 12 1 2025 06 07 Exploring the Relationship Between Burnout, Mental Health, and Psychosocial Factors Among Nurses 20 26 10.34172/ehsj.26149 EN Reza Jafari Nodoushan https://orcid.org/0000-0002-4797-0931 Shima Eyni https://orcid.org/0000-0003-3780-8436 Farzan Madadizadeh https://orcid.org/0000-0002-5757-182X Mehdi Nasr Isfahani https://orcid.org/0000-0002-0236-6546 Mahdi Jafari Nodoushan https://orcid.org/0000-0002-9238-5694 Journal Article 10.34172/ehsj.26149 2024 02 09 2025 04 20 Background and aims: Nursing is a demanding profession associated with high levels of stress and burnout. In this study, a theoretical model was applied to investigate structural associations among burnout, mental health, and workplace psychosocial factors for nurses working in Isfahan province, Iran. Methods: This cross-sectional study was conducted among 416 nurses in Iran selected using a stratified sampling method. The required data were collected using the General Health Questionnaires, Copenhagen Burnout Inventory, and Copenhagen Psychosocial Questionnaire and then analyzed by SPSS-24 and Amos-24 software, correlation tests, and structural equation modeling. Results: Burnout was significantly correlated with poorer mental health, with the highest correlation coefficient related to the component of personal burnout (r=0.30, P<0.001). The results of the model revealed that burnout negatively impacted mental health (β=0.33, P=0.001) and psychosocial factors (β=-0.90, P=0.001). However, burnout did not have a significant indirect effect on psychosocial factors through mental health (P=0.08). Conclusion: Higher burnout levels were associated with poorer mental health and adverse workplace psychosocial conditions. Accordingly, organizational interventions should focus on reducing burnout to promote mental health and psychosocial factors.