Shahrekord University of Medical Sciences Epidemiology and Health System Journal 2980-7891 9 4 2022 11 05 Assessment of Health-Related Quality of Life of Tuberculosis Patients in Lagos State, Nigeria 178 183 10.34172/EHSJ.2022.32 EN Ezinwanyi Madukoma https://orcid.org/0000-0001-9386-9992 Olalekan Moses Olayemi https://orcid.org/0000-0003-3802-7703 Journal Article 10.34172/EHSJ.2022.32 2022 04 18 2022 10 19 Background and aims: Tuberculosis (TB) is a major public health disease threat in the world, particularly in Nigeria. The burden of TB infection could have a far-reaching effect on the psychological, physical, and social well-being of patients and consequently deterioration in their health-related quality of life (HRQOL). Accordingly, this study examined the HRQOL of TB patients in directly observed therapy (DOT) centers in Lagos State, Nigeria. Methods: The survey design was used for the study, and a total of twelve public DOT Centers were chosen as the study sites. A sample size of 310 was obtained using the Taro Yamane formula. A structured and validated questionnaire was applied to collect data. The World Health Organization Quality of Life Assessment-BREF tool was employed to assess HRQOL. Statistical analysis was conducted using SPSS software, version 23. Results: Based on the results, the overall status of the HRQOL of the studied TB patients was moderate (average weighted mean=2.48) on a 4-point scale. The finding of the study also highlighted the significant effect of TB on several domains of HRQOL. The psychological domain had the highest HRQOL score (x̅=2.60±0.64), while the environmental domain represented the lowest HRQOL score (x̅=2.31±0.63). Conclusion: Overall, the HRQOL of TB patients was at a moderate level. The disease had no negative impact on the HRQOL of TB patients across all domains. This finding calls upon strategies to ensure a healthy lifestyle and a conducive living physical environment.