Shahrekord University of Medical Sciences Epidemiology and Health System Journal 2980-7891 9 2 2022 06 01 Knowledge, Attitudes, and Practices Towards COVID-19 in Iran: A Population-Based Study 61 68 10.34172/ijer.2022.11 EN Samaneh Torkian https://orcid.org/0000-0002-7913-2801 Vahid Khosravi https://orcid.org/0000-0002-7994-800X Reza Etesami https://orcid.org/0000-0003-4141-8852 Zahra Jaafari https://orcid.org/0000-0002-2702-039X Mohammad Ali Morowatisharifabad https://orcid.org/0000-0002-4039-3932 Ali Ahmadi https://orcid.org/0000-0002-1588-2136 Narges Khanjani https://orcid.org/0000-0002-7235-9253 Journal Article 10.34172/ijer.2022.11 2021 07 11 2021 12 19 Background and aims: The novel coronavirus (COVID-19) epidemic has far been the biggest global health threat of the 21st century. Protective measures are still one of the most effective methods for controlling COVID-19. Practicing hygiene and control measures are largely influenced by knowledge and attitude towards COVID-19. This study aimed to investigate the knowledge, attitude, and practice of Iranians towards COVID-19 as well as the demographic factors related to it in April and May, 2020. Methods: The study population in this cross-sectional, descriptive-analytical, and web-based study included 3736 Iranian individuals who were collected via convenience sampling method. A validated Iranian knowledge, attitude, and practices (KAP) Questionnaire about COVID-19 was used for collecting the required data. Ordinal multivariate generalized estimating equations (GEEs) were applied to analyze data. Results: The majority of participants (88.1%) had considerable knowledge, the right attitude (91%), and good practices (90.3%). In the multivariate models, factors related to greater knowledge were age>20 years (P<0.001), living in the urban area (P=0.030), holding a master’s or doctoral degree (P=0.044), and a moderate financial status (P=0.001). Females displayed mor positive attitude (P=0.035). Variables related to more favorable practices were age>20 years (P<0.001), and having a good (P=0.003) or moderate (P=0.038) financial status. Conclusion: It was concluded that the participants had good knowledge and a positive attitude, as well as adopted sound practices regarding COVID-19. However, this conclusion might not have been generalizable to entire Iranian community; therefore, it was recommended that preventive measures against COVID-19 should receive continued monitoring and emphasis.