Shahrekord University of Medical Sciences Epidemiology and Health System Journal 2980-7891 5 1 2018 01 01 Multiple Sclerosis in Iran 30 33 10.15171/ijer.2018.07 EN Reza Sahebi Masoud Amiri Mohammad Saeid Jami REVIEW 10.15171/ijer.2018.07 Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highly disabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with a complex pathology and significant social and economic impact. MS is associated with dysfunction of parts of the nervous system which results in a range of signs and symptoms, including physical, mental, and sometimes psychiatric problems. There is no definite treatment for MS. Iran has been thought to be located in the low risk zone of MS prevalence. However, recent studies and investigations in some cities such as Isfahan, a central province of Iran, have suggested a medium-to-high risk level of MS prevalence. Pathophysiological processes in MS contribute to the disease course and clinical manifestations. Therefore, biomarkers that are indicators of these events would provide significant potential for diagnosis, prediction of disease course, and optimization of therapeutic responses. This review provides information on the prevalence of MS and some risk factors among Iranian people