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Epidemiol Health System J. 2024;11(3): 158-165.
doi: 10.34172/ehsj.26270
  Abstract View: 116
  PDF Download: 88

Meta-Analysis

Association Between Gallstone Disease and Kidney Stone Disease: A Systematic Review and Meta-analysis

Faramarz Beigi 1 ORCID logo, Alizamen Salehifard Jouneghani 2 ORCID logo, Saeid Heidari-Soureshjani 3 ORCID logo, Catherine MT Sherwin 4 ORCID logo, Ghorbanali Rahimian 5* ORCID logo

1 Department of Urology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Pediatrics, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Pediatric Clinical Pharmacology and Toxicology, Department of Pediatrics, Wright State University, Boonshoft School of Medicine, Dayton, Ohio, USA
5 Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Ghorbanali Rahimian, Email: rahimian29638@yahoo.com

Abstract

Background and aims: Gallstone disease (GSD) and kidney stone disease (KSD) have increased due to lifestyle in recent decades. This systematic review and meta-analysis aimed to investigate the association between these two diseases.

Methods: A comprehensive electronic database search was conducted before August 25, 2024. This systematic review and meta-analysis included observational studies. The meta-analysis employed a random-effects model to compute the overall summary estimates of the association between GSD and KSD using risk ratios with 95% confidence intervals (CIs) as the primary measure of the effect size. Heterogeneity was evaluated using chi-square tests, the I² statistic, and forest plots. Publication bias was assessed through Begg’s and Egger’s tests. A P value of less than 0.05 was considered statistically significant, and all analyses were performed using Stata 17 software.

Results: The meta-analysis included 9 studies encompassing 982847 participants. The pooled analysis revealed a statistically significant association between GSD and KSD, with a risk of 1.78 (95% CI: 1.572.03, P≤0.001). Begg’s and Egger’s tests demonstrated no significant bias (Begg’s test P=0.835, Egger’s test P=0.812). Variables such as study year, sample size, mean age of participants, mean follow-up, and study quality as determined by the Newcastle-Ottawa Scale (NOS) were examined, but none could significantly impact heterogeneity (P>0.10).

Conclusion: This systematic review and meta-analysis provide evidence of a significant association between GSD and KSD. Therefore, further investigation into the underlying mechanisms and potential risk factors is necessary.

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Submitted: 11 Sep 2024
Accepted: 22 Oct 2024
ePublished: 12 Nov 2024
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