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Epidemiol Health System J. 2024;11(2): 68-73.
doi: 10.34172/ehsj.26146
  Abstract View: 105
  PDF Download: 66

Original Article

Impact of Medical Factors on Mortality in Patients With End-Stage Renal Disease in the West of Iran: A Prospective Study

Meisam Khajevand Ahmadi 1 ORCID logo, Masoumeh Abbasi 2 ORCID logo, Mehdi Moradinazar 1 ORCID logo, Touraj Ahmadi Jouybari 3 ORCID logo, Hamidreza Omrani 4 ORCID logo, Behnam Yari Bajelani 1 ORCID logo, Tahereh Mohammadi Majd 1* ORCID logo, Masoud Ghadiri 5 ORCID logo

1 Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Health Information Technology, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Cardiovascular Research Center, Health Institute, Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Student Research committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Tahereh Mohammadi Majd, Email: tahereh_mohammadi@yahoo.com

Abstract

Background and aims: End-stage renal disease (ESRD) is a pervasive global health challenge with high mortality rates. This prospective study aimed to identify medical factors influencing mortality in ESRD patients.

Methods: Data from 149 ESRD patients registered at Imam Khomeini hospital in Kermanshah were analyzed. Only patients with a minimum of one-year follow-up were included. Univariate and multiple regression analyses were employed, and model evaluation utilized indicators such as the area under the receiver operating characteristic (ROC) curve, sensitivity, and specificity.

Results: Among 149 ESRD patients, 88 (59.1%) were male, and 37 (24.7%) experienced mortality. The average age of deceased patients was 63.59±15.74 years. Chronic glomerulonephritis was the underlying cause in 72 (48.3%) participants. Multiple regression revealed that age, diabetes, and a history of heart failure significantly correlated with mortality. ESRD patients with diabetes faced a 2.47-fold increased risk of death (95% confidence interval: 1.10 - 5.55). The model exhibited an area under the curve (AUC) of 0.70, with sensitivity and specificity of 51.35% and 75%, respectively.

Conclusion: Given the chronic nature of ESRD and elevated mortality, particularly among diabetic patients, intensified monitoring efforts are crucial for the prevention and management of diabetes in this population.

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Submitted: 12 May 2024
Accepted: 19 May 2024
ePublished: 15 Jun 2024
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