Epidemiol Health System J. 2023;10(4): 175-179.
doi: 10.34172/ehsj.25214
  Abstract View: 357
  PDF Download: 167

Original Article

Clinical Challenges of the COVID-19 Vaccines: Frequency of Serious Adverse Events After Immunization in Hospitalized Patients

Hamed Delam 1* ORCID logo, Atefeh Ghadri 1 ORCID logo, Zahra Keshtkaran 2 ORCID logo, Behzad Rezaei 3 ORCID logo, Sahar Akbarpoor 4 ORCID logo

1 Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran
2 Community Based Psychiatric Care Research Center, Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Surgery, Larestan University of Medical Sciences, Larestan, Iran
4 Imam Reza Teaching Hospital, Larestan University of Medical Sciences, Larestan, Iran
*Corresponding Author: Hamed Delam, Email: hameddelam8@yahoo.com


Background and aims: Today, the role of coronavirus disease 19 (COVID-19) vaccines in preventing the disease and reducing the severity of the disease is undeniable; however, there is a possibility of serious adverse events following immunization (sAEFI) that might be life-threatening. The present study was designed to identify the frequency of the most common sAEFI in hospitalized people after receiving the COVID-19 vaccine in the south of Iran.

Methods: This cross-sectional study was conducted in 2022. In total, since the start of the COVID-19 vaccination program in the city of Larestan, in the south of Iran, a total of 68 sick people have been hospitalized due to complications caused by the vaccine. The research tool of the present study was a standard checklist called the sAEFI of the COVID-19 vaccine.

Results: A total of 68 hospital cases were reviewed. The mean age of the individuals with sAEFI was 59.78±12.70 years, and 21 (56.8%) of them were females. Acute respiratory distress syndrome (ARDS) was the most common 24 (64.9%) sAEFI. Based on the results, 2 (5.4%) had acute coronary syndrome (ACS), 2 (5.4%) had Guillain-Barré syndrome, and 2 (5.4%) had a stroke.

Conclusion: It can be mentioned that there is always a possibility of sAEFI, but its frequency in the general population is extremely rare. However, the most common sAEFIs included adverse drug reactions, stroke, and Guillain-Barré syndrome. The readiness of health care staff for early detection of possible sAEFI can be effective in reducing the severity of the sAEFI.

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Submitted: 15 Jul 2023
Revision: 27 Nov 2023
Accepted: 28 Nov 2023
ePublished: 29 Dec 2023
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