Background and aims: The lack of reliable data on mortality in Iran until the last few decades has caused the early stages of the epidemiological transition to remain unknown. As such, the current study was an attempt to examine the stages and timing of the epidemiological transition in Iran in a historical effort.
Methods: This study is descriptive-analytical, and its data and information have been collected using the library method.
Results: The historical course of the emergence of epidemics in Iran after Islam to before the Islamic Revolution is divided into four periods: (1) The period after Islam to the Safavid period (650-1501 AD): The era of plague and famine, (2) Safavid to Qajar period (1501-1796 AD): The era of continued widespread outbreaks and intermittent occurrence of plague, (3) Qajar period (1796-1925 AD): The era of subsidence of the plague and widespread cholera, and finally (4) Pahlavi period (1925-1979 AD): The era of the decline of epidemic diseases.
Conclusion: The continuous and substantial reduction in deaths led simultaneously to a reduction in the incidence and scope of epidemics and an increase in chronic diseases, and this process is expected to accelerate in the future.