Abstract
Background and aims: Toxoplasmosis is a very common disease in the world and has two types,
including chronic and acute toxoplasmosis. In the chronic toxoplasmosis, the abnormality of tissue
function is negligible, but in acute toxoplasmosis, the function of the reticuloendothelial system is
interrupted and the assessment of Toxoplasma antibody with tissue enzymes is very essential in this
stage. In addition, in some conditions, serum ferritin increases in the acute phase of the infectious
disease. In congenital toxoplasmosis, the evaluation of biochemical factors and IgG avidity test is
important for detecting the acute congenital toxoplasmosis in pregnant women. Based on the
above-mentioned explanations, the present study aimed to evaluate the biochemical factors in
patients with acute toxoplasmosis (congenital toxoplasmosis) among the Iranian population using
electrochemiluminescence and IgG ELISA avidity.
Methods: The study was based on a comparative abundance study and was conducted from March to
June 2017. Material included 980 serum and amniotic fluid samples collected from human blood with
a high level of IgG antibody against Toxoplasma gondii in Rajaie Center, Tehran, Iran. The standard and
the main tests included the ELISA assay and the measurement of the liver transaminases (i.e., SGOT
and SGPT), along with/namely bilirubin and ferritin used to detect IgG antibodies and to evaluate the
acute toxoplasmosis, respectively. Finally, the results were analyzed by SPSS software.
Results: The results showed that the level of liver transaminases, namely, serum bilirubin and ferritin
increase in some patients with a high level of IgG avidity antibody against Toxoplasma gondii. For
example, the mean serum levels of SGOT was 108 IU/L in 120 patients with acute toxoplasmosis and
the mean serum bilirubin was about 5 mg/dL in 80 patients.
Conclusion: Overall, in acute congenital toxoplasmosis, the evaluation of IgG AVIDITY is regarded as
the first step and then the measurement of biochemical factors such as serum transaminases, serum
bilirubin, and serum ferritin is important.