Abstract
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to investigate the Role of Interleukin (IL-22) in Immune Response in human diseases. Methods: This study was a mini-review research to investigate the role of T helper 22 (Th22) in immune response. Results: IL-22 contributes to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A. IL-22 confirms regulation of antimicrobial proteins. Targeting the IL-22–IL-22R pathway may yield new therapeutic potential for the treatment of certain human diseases. Conclusion: IL-22 is expressed constitutively by LTi-like cells within the small intestine, a tissue that is under the careful immune balance between inflammation and tolerance. Gaining a better understanding of the expression and role of IL-22 in health and disease is important for development of IL-22 as a potential drug target IL-22 is expressed constitutively by LTi-like cells within the small intestine, a tissue that is under the careful immune balance between inflammation and tolerance. Obtaining a better understanding of the expression and role of IL-22 in health and disease is important for development of IL-22 as a potential drug target.